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Contents lists available at ScienceDirect
Annals of Epidemiology
Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women
a Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
b New Rochelle, NY
c Center for Health Innovations and Outcomes Research, Feinstein Institute for Medical Research, Northwell Health, Great Neck, NY
d Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA
e Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
Available online 22 September 2018
Body mass index
Purpose: The purpose of circulatory system study was to examine the association of type II diabetes and anthropo-metric variables with risk of pancreatic cancer among postmenopausal women.
Methods: Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cancer were diagnosed among 156,218 women over a median follow-up of approx-imately 18 years. Cox proportional hazards models were used to estimate the associations of study factors with pancreatic cancer risk.
Conclusions: In this study of postmenopausal women, central adiposity and, to a lesser extent, general adiposity and a history of diabetes, were associated with increased pancreatic cancer risk.
In the United States, pancreatic cancer is the eleventh most common cancer in men and the ninth most common cancer in women , with an estimated 27,970 cases in men and 25,700 cases in women in 2017. However, owing to its high lethality,
Disclosure: This work was supported by institutional funds from the Albert Ein-stein College of Medicine.
Conflict of interest: The authors declare no conflict of interest.
* Corresponding author. Department of Epidemiology and Population Health,
E-mail address: [email protected] (R. Arthur). 1 Equal contribution.
pancreatic cancer ranks fourth among causes of cancer death in both men and women . In view of its high fatality rate, the identification of modifiable risk factors for the disease is of urgent importance.